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BIBF0775
Item number: TGM-T5197-100mg
Description: BIBF0775 is a selective TGFbeta type I receptor (Alk5) inhibitor (IC50: 34 nM). Target: ALK, TGF-beta/Smad. Smiles: CCN(C)C(=O)c1ccc2\C(=C(\Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1. References: Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth...
| Application: | ALK5 inhibitor |
| CAS | 334951-90-5 |
| MW: | 494.63 D |
From 37.00€
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BIBF 0775
Item number: Cay37777-1
BIBF 0775 is an inhibitor of TGF-beta receptor type 1 (ALK5, IC50 = 34 nM). It is selective for ALK5 over VEGFR2 and PDGFRalpha (IC50s = 1,447 and 890 nM, respectively), as well as a panel of 30 other kinases at 1 µM. BIBF 0775 inhibits the phosphorylation of SMAD2 and SMAD3 in HaCaT cells (EC50 = 105 nM) and is not...
| Keywords: | (3Z)-N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide |
| Application: | ALK5 inhibitor |
| CAS | 334951-90-5 |
| MW: | 494.6 D |
From 52.00€
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