Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...

Description: Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 µM). Etoposide has antitumor activity and induces apoptosis and autophagy. Target: Autophagy, Antibacterial, Apoptosis, Mitophagy, Antibiotic,...

Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a...

An anticancer agent and topoisomerase inhibitor which induces apoptosis.