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Item number: Cay13601-10

The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...

Keywords:	N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide
Application:	Aurora B kinase inhibitor
CAS	331771-20-1
MW:	513.6 D

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ZM447439

Item number: LKT-Z4900.1

ZM447439 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer activity, inducing hyperploidy and apoptosis in osteosarcoma cells and inhibiting growth in mesothelioma cells. ZM447439 also induces apoptosis and inhibits...

Application:	Aurora A / B kinase inhibitor
CAS	331771-20-1
MW:	567.63 D

From 129.00€ *

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