Description: TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 µM). Target: Pim, Apoptosis. Smiles: C(=C1SC(=O)NC1=O)C2=CC(C(F)(F)F)=CC=C2. References: Lin YW, et al. A small molecule inhibitor of Pim...

Selective inhibitor of Pim-1 and Pim-2 protein kinases, Inducer of G1 phase cell cycle arrest, Inducer of p27Kip1, Inducer of apoptosis through the mitochondrial pathway, Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway, Downregulates c-myc, Inhibitor of PRAS40 phosphorylation and mTOR activity,...