3 products were found matching "3133-16-2"!

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Item number: TGM-T4580-100mg

Description: 4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING. Target: Nrf2. Smiles: C(CC(C(O)=O)=C)(OCCCCCCCC)=O. References: Mills EL, et al. Itaconate is an anti-inflammatory metabolite...

Application:	Prodrug, Nrf2 stabilization
CAS	3133-16-2
MW:	242.31 D

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4-octyl Itaconate

Item number: Cay25374-25

4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with...

Keywords:	2-methylene-butanedioic acid, 4-octyl ester
Application:	Prodrug, Nrf2 stabilization
CAS	3133-16-2
MW:	242.3 D

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Itaconic acid 4-octyl ester [4-Octyl itaconate]

Item number: AG-CR1-3700-M050

White powder. Soluble in DMSO (30mg/ml), ethanol (30mg/ml) or DMF (30mg/ml). Chemical. CAS: 3133-16-2. Formula: C13H22O4. MW: 242.3. Derivative of itaconate (AG-CN2-0426) with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it...

Keywords:	4-Octyl ester 2-methylene-butanedioic acid, 4-Octyl methylenesuccinate, beta-Monooctyl itaconate
CAS	3133-16-2
MW:	242,3 D

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