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Item number: Cay24669-1

ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 µM but...

Keywords:	alpha-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide
Application:	Voltage-gated sodium channel (Nav) blocker
CAS	313254-51-2
MW:	449.5 D

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