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ICA-121431
Item number: TGM-T7336-100mg
Description: ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. Target: Sodium Channel. Smiles: O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1....
| Keywords: | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl |
| Application: | Voltage-gated sodium channel (Nav) blocker |
| CAS | 313254-51-2 |
| MW: | 449.55 D |
From 40.00€
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ICA 121431
Item number: Cay24669-1
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 µM but...
| Keywords: | alpha-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide |
| Application: | Voltage-gated sodium channel (Nav) blocker |
| CAS | 313254-51-2 |
| MW: | 449.5 D |
From 43.00€
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