Description: Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic or eukaryotic cells transfected with hph or hyg resistance genes. Target:...

Hygromycin B is an aminoglycoside produced by Streptomyces hygroscopicus. The antibiotic interferes with the translation step of polypeptide synthesis of prokaryotes and eukaryotes. The antibiotic inhibits peptide chain elongation by preventing elongation-factor EF-2 dependent translocation. Hygromycin B is used as...

It is an antibiotic from Streptomyces hygrosxopicus. It is a preferential translation inhibitor in virus-infected cells. The inhibition of protein synthesis is a consequence of a complex formation of the antibiotic with the ribosomal sub unit of the 70S ribosome that induces a localized conformational change.

Hygromycin B is an aminoglycosidic antibiotic which inhibits protein synthesis in bacteria, fungi and mammalian cells and is used to select prokaryotic and eukaryotic cells that have been transfected with the Hygromycin gene (hyg, hph, HMA, HM+). Source: Streptomyces hygroscopicus , Purity (HPLC): > 76%, Bioassay:...