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Item number: Cay29727-1

GRA Ex-25 is a glucagon receptor (GCGR) antagonist (IC50s = 55 and 56 nM for the human and rat receptors, respectively). It inhibits adenylate cyclase activity induced by glucagon (Cay-24204) with a Ki value of 254 nM. GRA Ex-25 (3 mg/kg, i.v.) reduces glucagon-induced increases in blood glucose levels in...

Keywords:	N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-beta-alanine
Application:	Glucagon receptor (GCGR) antagonist
CAS	307983-31-9
MW:	563.6 D

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