Description: CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1' pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs. Target: MMP. Smiles:...

CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml. It is without effect against MMP-1, MMP-9 or TNF-alpha converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell...