Description: SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 µM/0.22 µM, able to transport through the blood-brain barrier. Target: DNA/RNA Synthesis, MEK. Smiles: NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F. References: Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 µM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much...