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zapnometinib
Item number: TGM-T9321-100mg
Description: Zapnometinib (ATR-002) is a MEK inhibitor. Target: Antibacterial, MEK, Influenza Virus. Smiles: OC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl. References: Laure M, et, al. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse...
| Keywords: | 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, ATR-002, PD0184264,... |
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 303175-44-2 |
| MW: | 409.55 D |
From 40.00€
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Zapnometinib
Item number: Cay38517-10
Zapnometinib is a MEK inhibitor (IC50 = 5.73 nM) and an active metabolite of CI-1040 (Cay-11580). It reduces viral titers in A549 and MDCK cells infected with influenza A (EC50s = 6.356 and 4.498 µM, respectively). Zapnometinib (50 mg/kg per day) increases survival in H1N1pdm09 influenza A-infected mice.Formal Name:...
| Keywords: | ATR-002, PD 0184264, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-benzoic acid |
| Application: | MEK inhibitor |
| CAS | 303175-44-2 |
| MW: | 409.6 D |
From 56.00€
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