Description: Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide. Target: NO Synthase, NOD, Endogenous Metabolite. Smiles: CN(C)N=CNCCC[C@H](N)C(O)=O. References: Anna M Wieczór, Radoslaw Wieczór, Arleta...

NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased...