Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. All-transretinoic acid (ATRA) and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem...

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...

Description: Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARalpha/beta/gamma (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis. Target: Retinoid Receptor, Autophagy,...

The active metabolite of vitamin A. A potential chemopreventive against skin, colon, and mammary tumors.

Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR), mediates cellular growth and differentiation. Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that...