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Ro 67-7476
Item number: TGM-T3478-100mg
Description: Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. Target: GluR. Smiles: Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1. References: Hemstapat K et al. A novel class of positive...
| Application: | Positive allosteric mGlu1 receptor modulator |
| CAS | 298690-60-5 |
| MW: | 319.39 D |
From 31.00€
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Ro 67-7476
Item number: Cay11993-10
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 µM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 µM. Ro 67-7476 increases the...
| Keywords: | 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine |
| Application: | Positive allosteric mGlu1 receptor modulator |
| CAS | 298690-60-5 |
| MW: | 319.4 D |
From 44.00€
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