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Item number: BPS-82711-1

BI-2865 is a non-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM).1

Keywords:	BI-2865, pan-KRAS inhibitor, KRAS inhibitor,
Application:	Non-covalent pan-KRAS inhibitor
CAS	2937327-93-8
MW:	465,57 D

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BI-2865

Item number: TGM-T72062-100mg

Description: BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative...

CAS	2937327-93-8
MW:	465.57 D

From 228.00€ *

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