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L-685458
Item number: TGM-T6870-100mg
Description: L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Target: Apoptosis, Gamma-secretase. Smiles: CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O. References: Shearman MS, et...
| Keywords: | L-685,458 |
| Application: | gamma-secretase inhibitor |
| CAS | 292632-98-5 |
| MW: | 672.85 D |
From 120.00€
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L-685,458
Item number: Cay14926-1
L-685,458 is an inhibitor of gamma-secretase (IC50 = 17 nM). It is selective for gamma-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM). L-685,458 inhibits production of amyloid-beta (1-40) (Abeta40, Cay-21617) and Abeta42 (Cay-20574) in Neuro2A cells...
| Keywords: | gamma-Secretase Inhibitor X,... |
| Application: | gamma-secretase inhibitor |
| CAS | 292632-98-5 |
| MW: | 672.9 D |
From 136.00€
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