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GPX4-IN-5
GPX4-IN-5

Item number: TGM-T77755-100mg

Description: GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 µM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC). Target: GPX. Smiles: O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CCl. References: Chen...
Application: Covalent GPX4 inhibitor
CAS 2922824-09-5
MW: 381.78 D
From 62.00€ *
Review
C18
C18

Item number: Cay39432-1

C18 is a covalent inhibitor of glutathione peroxidase 4 (GPX4, IC50 = 120 nM). It inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 breast cancer cells (IC50s = 10, 75, and 12 nM, respectively). C18 (10 and 20 µM) increases lipid peroxidation and oxidized malondialdehyde (MDA) levels in MDA-MB-231 cells, an...
Keywords: 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide
Application: Covalent GPX4 inhibitor
CAS 2922824-09-5
MW: 381.8 D
From 40.00€ *
Review