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Roflumilast N-oxide
Item number: TGM-T4462-100mg
Description: Roflumilast N-oxide is an inhibitor of PDE type 4. Target: PDE. Smiles: [O-][n+]1cc(Cl)c(NC(=O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1. References: Victoni T,etal.Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.Int Immunopharmacol....
| Application: | PDE4 inhibitor |
| CAS | 292135-78-5 |
| MW: | 419.21 D |
From 31.00€
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Roflumilast N-oxide
Item number: Cay33975-10
Roflumilast N-oxide is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 2 nM) and an active metabolite of the PDE4 inhibitor roflumilast (Cay-15141). It is selective for PDE4 over PDE1-3 and PDE5 (IC50s = >10,000 nM for all). It reduces TNF-alpha-induced ICAM-1 and eotaxin levels when used in combination with...
| Keywords: | 3-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)-benzamide |
| Application: | PDE4 inhibitor |
| CAS | 292135-78-5 |
| MW: | 419.2 D |
From 85.00€
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