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BMS 299897
Item number: TGM-T14673-10mg
Description: BMS 299897 is a sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for inhibiting Abeta production in HEK293 cells stably overexpressing amyloid precursor protein (APP). Target: Gamma-secretase, Beta Amyloid. Smiles: C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O. References:...
| Application: | Gamma-secretase inhibitor |
| CAS | 290315-45-6 |
| MW: | 511.94 D |
From 52.00€
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BMS-299897
Item number: Cay35777-1
BMS-299897 is an inhibitor of gamma-secretase. It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively). BMS-299897 (0.1-1 nmol/animal) reduces increases in amyloid-beta (1-42) (Abeta42) levels induced...
| Keywords: | 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid |
| Application: | Gamma-secretase inhibitor |
| CAS | 290315-45-6 |
| MW: | 511.9 D |
From 39.00€
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