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Item number: TGM-T3528-100mg

Description: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in...

Keywords:	ICA-17043
Application:	Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
CAS	289656-45-7
MW:	323.34 D

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Senicapoc

Item number: Cay29679-50

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Cay-11016, IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per...

Keywords:	ICA-17043, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-benzeneacetamide
Application:	KCNN4 (IKCa1/KCa3.1) inhibitor
CAS	289656-45-7
MW:	323.3 D

From 44.00€ *

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