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Item number: TGM-T1676-100mg

Description: Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications...

Keywords:	ZD 4522
Application:	Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR)
CAS	287714-41-4
MW:	481.54 D

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Rosuvastatin

Item number: Cay12029-5

Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...

Keywords:	ZD 4522,...
Application:	HMG-CoA reductase inhibitor
CAS	287714-41-4
MW:	481.5 D

From 76.00€ *

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