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Apratastat
Item number: TGM-T14312-10mg
Description: Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-alpha converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-alpha in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex...
| Application: | Targets disintegrin and metalloproteinase domain-containing protein 17 (ADAM17, TACE, CD156b) |
| CAS | 287405-51-0 |
| MW: | 414.5 D |
From 147.00€
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TMI-005
Item number: Cay29016-1
TMI-005 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-alpha converting enzyme (ADAM17/TACE), matrix metalloproteinase-1 (MMP-1), and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively). It inhibits LPS-induced TNF-alpha release in isolated human whole blood (IC50 = 144 ng/ml)....
| Keywords: | Apratastat, (3S)-N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide |
| Application: | ADAM17 / MMP-1 / MMP-13 inhibitor |
| CAS | 287405-51-0 |
| MW: | 414.5 D |
From 61.00€
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