WLB-89462 is a ligand of sigma intracellular receptor 2 (sigma2 receptor). It selectively binds to the sigma2 receptor (Ki = 13 nM) over the sigma1 receptor (Ki = 1,777 nM). WLB-89462 (10 µM) prevents decreases in the number of dopaminergic neurons in an in vitro model of neurodegeneration using primary rat neurons...

Description: WLB-89462 (Compound 20c) is a selective sigma2 receptor ligand with a K i of 13 nM, demonstrating neuroprotective properties and the capacity to ameliorate Abeta peptide-induced short-term memory impairment in rats. It exhibits a favorable ADMET profile, featuring good solubility, lack of CYP...