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Item number: TGM-T4463-100mg

Description: Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC). Target: PARP. Smiles:...

Keywords:	AG014699, AG-14447, PF-01367338
Application:	Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1)
CAS	283173-50-2
MW:	323.36 D

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Rucaparib

Item number: Cay15643-1

Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is...

Keywords:	AG-014447, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
Application:	Potent, cell-permeable PARP-1 inhibitor
CAS	283173-50-2
MW:	323.4 D

From 43.00€ *

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