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Item number: Cay41446-10

EM12-SO2F is a covalent inhibitor of cereblon (CRBN, IC50 = 0.88 nM). It inhibits the degradation of Ikaros family zinc finger protein 1 (IKZF1) induced by the thalidomide derivative lenalidomide (Cay-14643) in MOLT-4 lymphoblasts when used at a concentration of 1 µM.Formal Name:...

Keywords:	2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
Application:	Covalent cereblon inhibitor
CAS	2803819-61-4
MW:	326.3 D

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