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RMC-6236
Item number: Cay41982-1
RMC-6236 is a non-covalent inhibitor of GTP-bound RAS. It binds to peptidyl-prolyl cis-trans isomerase A (PPIase A), also known as cyclophilin A (CypA, Kd = 55.3 nM) to form a binary complex that then binds to wild-type K-Ras, K-Ras(G12V), and K-Ras(G12D) (Kds = 131, 364, and 154 nM, respectively). RMC-6236 forms a...
| Keywords: | (1S,2S)-N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-... |
| Application: | Non-covalent GTP-bound Ras inhibitor |
| CAS | 2765081-21-6 |
| MW: | 811.1 D |
From 108.00€
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RMC-6236
Item number: TGM-T74698-100mg
Description: RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer. Target: Ras. Smiles: O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C=4C=C(C=NC4C(OC)C)N5CCN(C)CC5)CC)C=6N=C(SC6)CC(NC(=O)C7CC7C)C(=O)N8NC1CCC8. References: Ethan AHLER, et...
| Keywords: | RMC6236, RMC-6236 |
| CAS | 2765081-21-6 |
| MW: | 811.05 D |
From 290.00€
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