Description: SD 0006 (SD-06) is a MAPK p38 alpha inhibitor with an IC50 of 110 nM, indicated for the treatment of arthritis. Target: p38 MAPK, Autophagy. Smiles: OCC(=O)N1CCC(CC1)c1n[nH]c(c1-c1ccncn1)-c1ccc(Cl)cc1. References: Walker J K , Selness S R , Devraj R V , et al. Identification of SD-0006, a potent diaryl...

Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine

SD-06 is an ATP-competitive inhibitor of p38alpha MAPK (IC50 = 0.016 µM). It is selective for p38alpha over p38beta, p38gamma, and p38delta MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all). SD-06 inhibits LPS-induced TNF-alpha, IL-6, and...