Description: Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with the activation of pathways involved in wound...

Myoseverin is a trisubstituted purine which binds microtubules, reversibly altering cellular function. At 20 µM, it directly binds tubulin and disrupts the structure of the microtubule cytoskeleton, resulting in myotube fission. Myoseverin arrests cell cycle in the G2/M phase, followed by DNA synthesis and cell...