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SB 415286
Item number: TGM-T6659-100mg
Description: SB 415286 is a potent GSK3alpha inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3beta. Target: GSK-3, Apoptosis. Smiles: Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl. References: Coghlan MP, et al. Chem Biol, 2000, 7(10), 793-803.
| Keywords: | SB415286 |
| Application: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359.72 D |
From 42.00€
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SB-415286
Item number: Cay10010247-1
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and...
| Keywords: | 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Application: | GSK inhibitor |
| CAS | 264218-23-7 |
| MW: | 359.7 D |
From 44.00€
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SB415286
Item number: AG-CR1-3658-M001
Yellow solid. Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.9µM), Stimulates glycogen synthesis in liver cells and induces...
| Keywords: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Application: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359,7 D |
From 33.00€
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