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PD-173955
Item number: SYN-1061-M001
PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of...
| Keywords: | PD173955, PD-173,955 |
| Application: | BCR-Abl inhibitor |
| CAS | 260415-63-2 |
| MW: | 443,4 D |
From 218.00€
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PD 173955
Item number: Cay30618-5
PD 173955 is a tyrosine kinase inhibitor. It inhibits c-Src, Yes, and LCK (IC50s = 25, 22, and 5 nM, respectively), as well as Bcr-Abl and c-Kit (IC50s = 1-2 and 25 nM, respectively), and is selective for these kinases over the insulin receptor (InsR), alpha-FGFR, basic FGFR (bFGFR), PDGFR, and PKC. PD 173955 (5,000...
| Keywords: | 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Application: | Tyrosine kinase inhibitor |
| CAS | 260415-63-2 |
| MW: | 443.4 D |
From 43.00€
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