Description: Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-kappaB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-kappaB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L). Target:...

Nimbolide is a terpenoid lactone first isolated from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models. It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the...

RTECS: GY2370000 Source/Host Chemicals: Plant. Appearance: White to faint yellow powder. Solubility: Soluble in DMSO or DMF (10mg/ml). Identity: Determined by 1H-NMR. InChi Key: JZIQWNPPBKFOPT-FTCZZEDLSA-N Smiles:...