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Item number: Cay20732-1

CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1, Ki = 2.7 nM). It is selective for CRF1 over CRF2 (Ki = >10 µM). CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open...

Keywords:	N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride
CAS	257639-98-8
MW:	401 D

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