Description: CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-kappaB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN). Target: NF-kappaB, TLR, MyD88. Smiles: CCCc1nc2c(N)nc3ccccc3c2s1....

CL075 is a toll-like receptor 8 (TLR8) agonist. It induces NF-kappaB activation in a reporter assay using HEK293 cells expressing recombinant human TLR8 and TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1 to 10 µM. In vivo, CL075 induces...