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Item number: TGM-T85023-10mg

Description: TG11-77 hydrochloride is a potent, selective, and water-soluble EP2 receptor antagonist that is brain-permeable, demonstrating a KB value of 9.7 nM. Target: Others. Smiles: C(CNC(=O)C=1C=NC(NC2=CC(C)=CC(C)=N2)=NC1)C=3C=4C(NC3C)=CC=CC4.Cl

Application:	Prostanoid EP2 receptor antagonist
CAS	2550393-38-7
MW:	436.94 D

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TG11-77 (hydrochloride)

Item number: Cay30188-5

TG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM). It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 µM) inhibits the expression of genes encoding COX-2, IL-1beta, and IL-6 induced by...

Keywords:	2-((4,6-dimethylpyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide, monohydrochloride
Application:	Prostanoid EP2 receptor antagonist
CAS	2550393-38-7
MW:	436.9 D

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