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L-778123 hydrochloride
Item number: TGM-T3182-100mg
Description: The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination. Target: Telomerase, Transferase. Smiles: Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O. References: Lobell RB, et al. Mol Y Ther. 2002 Jul,1(9):747-58.
| Keywords: | L 778123 |
| Application: | Protein farnesyltransferase / geranylgeranyltransferase type-I inhibitor |
| CAS | 253863-00-2 |
| MW: | 442.34 D |
From 38.00€
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L-778,123 (hydrochloride)
Item number: Cay22940-5
L-778,123 is a dual inhibitor of farnesyl transferase (FTase, IC50 = 2 nM) and geranylgeranyl transferase type I (GGTase I, IC50 = 98 nM). It inhibits prenylation of the FTase and GGTase I substrates HDJ2 and RAP1A in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively). L-778,123 (1-300 µM) also...
| Keywords: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-benzonitrile, monohydrochloride |
| Application: | Protein farnesyltransferase / geranylgeranyltransferase type-I inhibitor |
| CAS | 253863-00-2 |
| MW: | 442.3 D |
From 130.00€
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