Description: Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells,...

Ferroptocide is an inhibitor of thioredoxin (Trx) and a derivative of pleuromutilin (Cay-19452). It inhibits Trx activity in ES-2 ovarian cancer cells when used at a concentration of 20 µM and is cytotoxic to ES-2 cells (IC50 = 1.6 µM). Ferroptocide (5 µM) induces ferroptosis in ES-2 cells, an effect that can be...