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Item number: Cay40463-10

GMB 475 is a proteolysis-targeting chimera (PROTAC) containing the Bcr-Abl inhibitor GNF-5 (Cay-16254) conjugated to VHL ligand 1 (Cay-21591). It induces degradation of Bcr-Abl with a half-maximal degradation concentration (DC50) value of 340 nM. GMB 475 selectively inhibits the proliferation of K562 chronic myeloid...

Keywords:	(4R)-3-methyl-N-[2-[2-[4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]phenoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[...
Application:	Bcr-Abl degradation driving PROTAC
CAS	2490599-18-1
MW:	861.9 D

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GMB-475

Item number: BPS-82054

GMB-475 acts as a degrader of BCR-ABL 1 tyrosine kinase and as a recruiter of the E3 ligase Von Hippel Lindau (VHL) resulting in ubiquitination and subsequent degradation of oncogenic fusion proteins.

Application:	Protac(R) reagent
CAS	2490599-18-1
MW:	861,9 D

935.00€ *

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