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CU-115
Item number: TGM-T9645-100mg
Description: CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-alpha and IL-1beta activated by R-848 in THP-1 cells. Target: TLR. Smiles: Fc1cccc(I)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1. References: Rosaura...
| Keywords: | N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide |
| Application: | TLR8 antagonist |
| CAS | 2471982-20-2 |
| MW: | 569.21 D |
From 52.00€
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CU-115
Item number: Cay29815-1
CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 µM). It is selective for TLR8 over TLR7 (IC50 = >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20...
| Keywords: | N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-benzamide |
| Application: | TLR8 antagonist |
| CAS | 2471982-20-2 |
| MW: | 569.2 D |
From 158.00€
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