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JKE-1674
Item number: TGM-T37314-100mg
Description: JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. Target: GPX. Smiles: O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1. References: Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020,16(5):482-483.
| Application: | Glutathione peroxidase 4 (GPX4) inhibitor |
| CAS | 2421119-60-8 |
| MW: | 451.3 D |
From 48.00€
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JKE-1674
Item number: Cay30784-1
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 (Cay-23282). JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 µM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1...
| Keywords: | (E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one |
| Application: | Glutathione peroxidase 4 (GPX4) inhibitor |
| CAS | 2421119-60-8 |
| MW: | 451.3 D |
From 77.00€
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