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JQAD1
Item number: TGM-T41180-100mg
Description: JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC(R), DC50= 31.6 nM), comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1...
| Application: | PROTAC, p300 degradation |
| CAS | 2417097-18-6 |
| MW: | 932.95 D |
From 134.00€
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JQAD1
Item number: Cay39566-1
JQAD1 is a proteolysis-targeting chimera (PROTAC) composed of the p300 and CREB-binding protein (CBP) inhibitor A-485 (Cay-24119) conjugated to a cereblon (CRBN) ligand. It selectively induces the degradation of p300 over CBP in Kelly MYCN-amplified neuroblastoma cells when used at a concentration of 10 µM for 24...
| Keywords: | (R,S)-JQAD1,... |
| Application: | PROTAC, p300 degradation |
| CAS | 2417097-18-6 |
| MW: | 933 D |
From 115.00€
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