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Item number: Cay26387-1

MRK-740 is an inhibitor of the lysine methyltransferase PR/SET domain 9 (PRDM9, IC50 = 80 nM). It inhibits PRDM9-dependent trimethylation of ectopic histone H3K4 (IC50 = 0.8 µM) and endogenous H3K4 in HEK293 cells in a concentration-dependent manner. MRK-740 induces meiotic defects in mouse spermatocytes.Formal...

Keywords:	4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-1,4,9-triazaspiro[5.5]undecane
Application:	PRDM9 inhibitor
CAS	2387510-80-5
MW:	464.6 D

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MRK-740

Item number: TGM-T62957-100mg

Description: MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation. Target: Histone Methyltransferase. Smiles: COc1cc(OC)cc(c1)-c1noc(n1)N1CCN(C)C2(CCN(CC2)c2ccnc(C)c2)C1. References: Abdellah...

CAS	2387510-80-5
MW:	464.56 D

From 103.00€ *

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