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RBN-2397
Item number: TGM-T12695-100mg
Description: RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM. Target: PARP. Smiles: C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F. References: Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor...
| Application: | Targets poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30] (PARP7S) |
| CAS | 2381037-82-5 |
| MW: | 523.43 D |
From 131.00€
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RBN-2397
Item number: Cay33558-1
RBN-2397 is an inhibitor of poly(ADP-ribose) polymerase 7 (PARP7). It stabilizes wild-type PARP7 levels, but not levels of the catalytically inactive mutant PARP7H532A, in COS-1 cells expressing wild-type or mutant PARP7, respectively, when used at a concentration of 100 nM. RBN-2397 (100 nM) also decreases...
| Keywords: | 5-[[(1S)-1-methyl-2-[3-oxo-3-[4-[5-(trifluoromethyl)-2-pyrimidinyl]-1-piperazinyl]propoxy]ethyl]amino]-4-(trifluoromethyl)... |
| Application: | PARP7 inhibitor |
| CAS | 2381037-82-5 |
| MW: | 523.4 D |
From 103.00€
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RBN-2397
Item number: AG-CR1-3547-M005
Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml) or DMF (1mg/ml). Insoluble in water. Identity: Determined by 1H-NMR InChi Key: UQZCQKXJAXKZQH-LBPRGKRZSA-N Smiles: O=C1NN=CC(N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)=C1C(F)(F)F RBN-2397 is a potent NAD+ competitive small molecule...
| Keywords: | Atamparib,... |
| Application: | PARP7 inhibitor |
| CAS | 2381037-82-5 |
| MW: | 523.4 D |
From 149.00€
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