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PF-07220060
Item number: Cay41858-10
PF-07220060 is an inhibitor of cyclin-dependent kinase 4 (Cdk4, Ki = 0.6 nM for Cdk4/cyclin D1). It is selective for Cdk4 over Cdk6 (Ki = 13.9 nM for Cdk6/cyclin D3). PF-07220060 in combination with fulvestrant (Cay-10011269) increases senescence in HR+HER2- breast cancer cells in vitro but does not induce cell...
| Keywords: | Atirmociclib,... |
| Application: | Cdk4 inhibitor |
| CAS | 2380321-51-5 |
| MW: | 463.9 D |
From 239.00€
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CDK4/6-IN-6
Item number: TGM-T39957-100mg
Description: CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. Target: CDK. Smiles: CC(C)n1c(nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCOC[C@H]2O)ncc1Cl)C(C)(C)O. References: Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as...
| Application: | Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor |
| CAS | 2380321-51-5 |
| MW: | 463.93 D |
From 112.00€
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