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ACBI1
Item number: Cay36612-1
ACBI1 is a proteolysis-targeting chimera (PROTAC) composed of a ligand for BRM, also known as SMARCA2, BRG1, also known as SMARCA4, and polybromo-1D (PBRM1), which are components of switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes, conjugated to a von Hippel-Lindau (VHL) E3 ligase ligand. It...
| Keywords: | (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol... |
| Application: | BRM / BRG1 / PBRM1 degradation driving PROTAC |
| CAS | 2375564-55-7 |
| MW: | 936.1 D |
From 98.00€
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ACBI1
Item number: TGM-T17350-100mg
Description: ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker,...
| Application: | PROTAC (BRM/BRG1/PBRM1 degradation) |
| CAS | 2375564-55-7 |
| MW: | 936.1 D |
From 98.00€
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