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GSK8612
Item number: TGM-T5540-100mg
Description: GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8). Target: IkappaB/IKK. Smiles: Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1. References: Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett....
| Application: | TBK1 inhibitor |
| CAS | 2361659-62-1 |
| MW: | 520.33 D |
From 40.00€
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GSK8612
Item number: Cay28813-10
GSK8612 is an inhibitor of TANK-binding kinase 1 (TBK1, IC50 = 158 nM). It is selective for TBK1 over a panel of 285 kinases. GSK8612 inhibits IFN-alpha release in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with polyinosinic-polycytidylic acid (poly(I:C), IC50 = 794 nM). It also inhibits...
| Keywords: | 4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]-benzenesulfonamide |
| Application: | TBK1 inhibitor |
| CAS | 2361659-62-1 |
| MW: | 520.3 D |
From 92.00€
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