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Item number: TGM-T4443-100mg

Description: AZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 µM for ATM in cells. Target: ATM/ATR. Smiles: CNC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)-c1ccccc1. References: Karlin J, et al. Orally Bioavailable and Blood-Brain...

Application:	ATM inhibitor
CAS	2288709-96-4
MW:	328.37 D

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AZ 32

Item number: Cay26380-1

AZ 32 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 50s = 4.6 and >4.6 µM, respectively). AZ 32 enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53. It increases survival in a U87-281G glioma orthotopic mouse xenograft model, as...

Keywords:	N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Application:	ATM inhibitor
CAS	2288709-96-4
MW:	328.4 D

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