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Item number: TGM-T5486-100mg

Description: RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. Target: DNA, cGAS. Smiles: Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1. References: Vincent J, et al. Small molecule inhibition of cGAS reduces interferon...

Keywords:	RU320521
Application:	cGAS inhibitor
CAS	2262452-06-0
MW:	415.23 D

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RU-521

Item number: Cay31765-5

RU-521 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.11 µM). It inhibits dsDNA-, but not IFN-beta- or 5'ppp-HP20 RNA-, induced IFN-beta1-dependent gene expression in reporter assays and does not inhibit Pam3CSK4-, poly(I:C)-, or LPS-induced Il6 mRNA expression in RAW 264.7 cells, indicating...

Keywords:	RU-320521, 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone
Application:	cGAS inhibitor
CAS	2262452-06-0
MW:	415.2 D

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