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Item number: TGM-T78209-50mg

Description: Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutaneous fibroneruroma, and neurofibromatosis [1]. Target: MEK. Smiles: O=C(NOCCO)C=1C=2C=CC=NC2N(C1NC3=CC=C(I)C=C3F)C

Application:	MEK1 inhibitor
CAS	2252314-46-6
MW:	470.24 D

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Nedometinib

Item number: Cay40465-1

Nedometinib is a MEK1 inhibitor (IC50 = 135 nM). It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application...

Keywords:	NFX-179, 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
Application:	MEK1 inhibitor
CAS	2252314-46-6
MW:	470.2 D

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