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AZD3229
Item number: TGM-T5409-100mg
Description: AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. Target: c-Kit. Smiles: COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(nn4)C(C)C)cc3)ncnc2c1. References: Kettle JG, et al. Discovery...
| Application: | c-Kit-driven cell proliferation inhibitor |
| CAS | 2248003-60-1 |
| MW: | 479.51 D |
From 61.00€
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AZD 3229
Item number: Cay27908-1
AZD 3229 is an inhibitor of c-Kit-driven cell proliferation. It selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM). AZD 3229 (20 mg/kg twice per day) induces tumor regression in a Ba/F3...
| Keywords: | N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide |
| Application: | c-Kit-driven cell proliferation inhibitor |
| CAS | 2248003-60-1 |
| MW: | 479.5 D |
From 92.00€
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