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Item number: Cay41536-10

Acoramidis is a kinetic stabilizer of transthyretin (TTR). It selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively, Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all). Acoramidis...

Keywords:	AG-10, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro-benzoic acid, monohydrochloride
Application:	TTR kinetic stabilizer
CAS	2242751-53-5
MW:	328.8 D

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